Drug interactions on P-glycoprotein transport level and its application / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1916-1920, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-354162
Responsible library:
WPRO
ABSTRACT
Potential drug interactions on P-glycoprotein transport level were discussed in this article. As an efflux transporter protein widely distributed in various tissues, P-glycoprotein plays an important role in many drugs interactions, via affecting the metabolic process to alter the concentration of drug in plasma and tissue. Interactions between herb and western drug may occur by inducing or inhibiting P-glycoprotein, resulting in either efficacy enhancement or adverse effects. So it is important for clinical drug use by rational utilization of the interaction between herb and western drug which medicated by P-glycoprotein.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
ATP Binding Cassette Transporter, Subfamily B
/
Protein Transport
/
Drug Interactions
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Document type:
Article