Advances in the study of polymeric micelles used in oral administration / 药学学报
Acta Pharmaceutica Sinica
; (12): 560-564, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-354591
Responsible library:
WPRO
ABSTRACT
Polymeric micelles which are self-assembled from amphiphilic copolymers are thermodynamically stable, and they can solubilize hydrophobic drugs by the hydrophilic core. Many excellent active compounds are confined because of general low oral bioavailability due to poor solubility. Take into account from the two points above, polymeric micelles may be used as proper oral carrier to improve the dissolubility of hydrophobic drugs, and enhance the permeation though gastrointestinal tract, therefore, the pharmacodynamics is elevated. Meanwhile, the segments in copolymers are multivariate, so many kinds of micelles can be obtained, such as, pH- or thermo- sensitive as well as mucoadhesive ones. The modified micelles can alter drug release profiles while solubilizing them, that is why the oral bioavailability increase further. In this review, recent progress of polymeric micelles used in oral administration is summarized, and the prospect of polymeric micelles' application in this field is also evaluated.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 5: Medicines, vaccines and health technologies
Database:
WPRIM (Western Pacific)
Main subject:
Polyethylene Glycols
/
Polymers
/
Silymarin
/
Solubility
/
Drug Carriers
/
Pharmacokinetics
/
Pharmaceutical Preparations
/
Biological Availability
/
Chemistry
/
Administration, Oral
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Document type:
Article