Sequential changes in biomechanical competence of femoral neck and marrow cavity of proximal femur in ovariectomized rats / 浙江大学学报·医学版
Zhejiang Daxue xuebao. Yixue ban
; (6): 432-446, 2005.
Article
in Zh
| WPRIM
| ID: wpr-355189
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the sequential changes in biomechanical competence of the femoral neck and marrow cavity of the proximal femur in ovariectomized rats.</p><p><b>METHODS</b>Bone mineral density (BMD) and biomechanical properties of the femoral neck and the structural dimension of the proximal femur were measured 0, 3, 6, 9, 12, 15, 18, 21 weeks after ovariectomy (OVX) or sham operation (Sham) in 6-month-old female SD rats.</p><p><b>RESULTS</b>The BMD of femoral neck in OVX rats was significantly lower than that in Sham group 6 weeks after operation, (0.195 +/-0.028) g/mm(2) vs (0.225 +/-0.036) g/mm(2) (P=0.03). Nine weeks after operation,the failure load of femoral neck decreased about 10% in OVX group to that in Sham group, (89.6 +/-7.7)N vs (96.7 +/-7.5)N (P=0.05). The medullary cavity of proximal femur started to show difference 15 weeks after operation (3.834 +/-0.115)mm(2) vs (3.713 +/-0.114) mm(2) (P=0.03).</p><p><b>CONCLUSION</b>BMD loss after ovariectomy is associated with a medullary expansion in proximal femur and biomechanical strength deterioration in femoral neck, which might be an important factor of prostheses loosening in the postmenopausal osteoporotic women.</p>
Full text:
1
Database:
WPRIM
Main subject:
Biomechanical Phenomena
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Prosthesis Failure
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Ovariectomy
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Random Allocation
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Bone Density
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Osteoporosis, Postmenopausal
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Rats, Sprague-Dawley
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Arthroplasty, Replacement, Hip
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Femur
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Femur Neck
Type of study:
Clinical_trials
Limits:
Animals
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Female
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Humans
Language:
Zh
Journal:
Zhejiang Daxue xuebao. Yixue ban
Year:
2005
Document type:
Article