Detection of serum antibodies against Japanese encephalitis virus in bats in Hainan and Guangdong Provinces of China / 南方医科大学学报
Journal of Southern Medical University
; (12): 720-723, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-355296
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the prevalence of serum antibodies against Japanese encephalitis virus (JEV) in bats.</p><p><b>METHODS</b>Blood samples from the heart were obtained from bats captured in Guangdong and Hainan Provinces in 2013. The anti-JEV antibodies in bat sera were tested using indirect ELISA and virus neutralization test.</p><p><b>RESULTS</b>A total of 201 bat serum samples were tested, in which the total positivity rate of anti-JEV antibodies was 46.27% (93/201). The positive rate of anti-JEV antibodies in bats from Hainan and Guangdong Provinces was 88.89% (48/54) and 30.61% (45/147), respectively. All the samples from Rousettus leschenaultia, Miniopterus schreibersii, Pipistrellus abramus, and Rhinolophus macrotis were positive for anti-JEV antibodies, and up to 95.56% (43/45) of the samples from Miniopterus schreibersii (from Hainan Province) yielded positive results. Of the 28 samples with positive results by indirect ELISA, 15 showed positive results in virus neutralization test (53.57%) with neutralization antibody titers ranging from 110 to 128.22.</p><p><b>CONCLUSION</b>Bats from different regions and of different species can be naturally infected with JEV and have a high prevalence of anti-JEV antibodies in their sera. The role of bats in the natural cycle of JEV awaits further study.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Virology
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
Neutralization Tests
/
China
/
Chiroptera
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Encephalitis Virus, Japanese
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Allergy and Immunology
/
Antibodies, Viral
Type of study:
Diagnostic study
Limits:
Animals
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Document type:
Article