Effects of noise exposure on event-related potential P300 and mechanism in hippocampus of rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 404-407, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-356240
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To study the effects of noise on event-related potential(ERP) and its mechanism in hippocampus in rats.</p><p><b>METHODS</b>Male SD rats were divided into 2 groups control group (CG) and noise exposure group(NG). The rats in NG were exposed to white noise 105 dB SPL for 2.5 h/d x 20 d. P300 were recorded at parietal bone in rats. The Nissl body, NMDAR2B and [Ca2+]i of neurons in hippocampus were analyzed.</p><p><b>RESULTS</b>The peak latency (PL) of ERP P3a, P3 and P3b in NG were significantly longer than that in CG in the 14th and 20th exposure day. The amount of Nissl body in dentate gyrus (DG) and CA1 region and NMDAR2B in DG, CA1 and CA3 region of hippocampus of NG were significantly decreased than those of CG as well, while the concentration of Ca2+ in neurons increased markedly in NG.</p><p><b>CONCLUSION</b>Decreased Nissl body and NMDAR2B and increased [Ca2+]i in hippocampus in long-term noise exposed rats might cause the change of ERP P300.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
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Random Allocation
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Calcium
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Rats, Sprague-Dawley
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Receptors, N-Methyl-D-Aspartate
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Event-Related Potentials, P300
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Environmental Exposure
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Hippocampus
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Metabolism
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Neurons
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2009
Document type:
Article