Therapeutic effect of levetiracetam add-on treatment for frontal lobe epilepsy in 105 children / 南方医科大学学报
Journal of Southern Medical University
; (12): 364-367, 2014.
Article
in Zh
| WPRIM
| ID: wpr-356920
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes in 24-hour video electroencephalogram (EEG) and epileptic attacks after levetiracetam add-on therapy in children with frontal lobe epilepsy and epileptiform discharges.</p><p><b>METHODS</b>A prospective study was carried out in 105 children with the frontal lobe epilepsy who received long-term treatment with 1 or 2 types of antiepileptic drug but still with epileptiform discharges in ECG. Levetiracetam add-on therapy was administered at the initial daily dose of 20 mg/kg (given in 2 doses) for 2 weeks followed by an increase of the dose to 30 mg/kg with a maintenance dose of 30-40 mg/kg. The changes in seizure attacks and 24-hour video-EEG monitoring after a 6-month therapy were observed.</p><p><b>RESULTS</b>Levetiracetam add-on therapy reduced epileptiform discharges in 55 children (52.3%) and resulted in significant changes in EEG (P<0.05). Of the 77 children with clinical seizures, complete seizure control was achieved in 12 cases after the therapy, and the seizure attacks were reduced in 28 cases, showing a total response rate of 51.9%; the reduction in seizure attacks was positively correlated with EEG improvement (P<0.001).</p><p><b>CONCLUSION</b>Levetiracetam add-on therapy can decrease epileptiform discharges in EEG and reduce clinical seizure attacks in children with frontal lobe epilepsy with only mild adverse reactions.</p>
Full text:
1
Database:
WPRIM
Main subject:
Piracetam
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Prospective Studies
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Treatment Outcome
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Epilepsy, Frontal Lobe
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Therapeutic Uses
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Drug Therapy
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Electroencephalography
/
Anticonvulsants
Type of study:
Observational_studies
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2014
Document type:
Article