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The expression and significance of chromogranin A and synaptophysin in adrenal gland tumors / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 486-488, 2005.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-358596
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of chromogranin A (CgA) and synaptophysin (Syn) for differential diagnosis of different kinds of adrenal gland tumors.</p><p><b>METHODS</b>The samples of 69 adrenal gland tumors and 4 normal adrenal glands were immunohistochemically analyzed for the expression of chromogranin A and synaptophysin. The statistical analysis of the data was performed using chi-square test.</p><p><b>RESULTS</b>In the normal adrenal gland, CgA and Syn was exclusively detected in the medulla. CgA was detected in all pheochromocytomas 25/25 (100%), and gave less or no expression in adrenocortical tumors. Syn was detected in adrenocortical adenomas 27/28 (96.4%), adrenocortical carcinoma 7/8 (87.5%), pheochromocytoma 24/25 (96.0%) and adrenal metastatic carcinoma 6/8 (75.0%), respectively.</p><p><b>CONCLUSION</b>There is statistically significant difference of CgA expression between adrenalcortical and adrenal medullary tumors, and also between benign and malignant pheochromocytomas. CgA and Syn are immunohistochemically reliable markers in the differential diagnosis of various kinds of adrenal gland tumors.</p>
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Pheochromocytoma / Synaptophysin / Adrenal Gland Neoplasms / Adrenocortical Carcinoma / Adrenocortical Adenoma / Diagnosis / Diagnosis, Differential / Chromogranin A / Genetics / Metabolism Type of study: Diagnostic study Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2005 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Pheochromocytoma / Synaptophysin / Adrenal Gland Neoplasms / Adrenocortical Carcinoma / Adrenocortical Adenoma / Diagnosis / Diagnosis, Differential / Chromogranin A / Genetics / Metabolism Type of study: Diagnostic study Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2005 Document type: Article
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