Role of GDNF in the behavior and cognitive impairment of mice induced by chronic stress and aging / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 52-56, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-358680
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of chronic stress on the spatial learning-memory and the role of glial cell line-derived neurotrophic factor (GDNF) of prefrontal cortex (PFC) and hippocampus (HP) in different age mice.</p><p><b>METHODS</b>The chronic stress model mice in 21 days with multiple chronic unpredictable stressors were applied. The spontaneous behavior and spatial learning-memory ability of mice were tested, using Open field and Morris water maze task, and the expression of GDNF in HP and PFC were detected by immunohistochemical method.</p><p><b>RESULTS</b>Compared with young mice, the spontaneous behaviors were significantly decreased and the spatial learning-memory function were significantly decreased (P < 0.05, P < 0.01) in aged mice. The GDNF expression in the CA3, DG of HP and PFC were significantly reduced in aged mice (P < 0.05, P < 0.01). After chronic stress, the spontaneous behaviors were remarkably decreased and the ability of spatial learning-memory of the stress group mice were significantly decreased (P < 0.05, P < 0.01) compared with those of the control group mice. The expression of GDNF in HP and PFC were remarkably reduced (P < 0.05, P < 0.01) in stress group mice. The aged stress mice had more serious changes after chronic stress.</p><p><b>CONCLUSION</b>The brain aging and chronic stress in mice causes behavioral changes and the damage of spatial learning-memory function, and which may be nearly related to the expression of GDNF in HP and PFC.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Stress, Physiological
/
Aging
/
Cerebral Cortex
/
Cognition Disorders
/
Maze Learning
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Glial Cell Line-Derived Neurotrophic Factor
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Hippocampus
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Metabolism
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Mice, Inbred Strains
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2013
Document type:
Article