Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 54-59, 2008.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-360003
Responsible library:
WPRO
ABSTRACT
Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies for the cavernous nerves (CNs), as therapies for prostate cancer and other pelvic malignancies often result in neuronal damage and debilitating loss of sexual function. Nitric oxide released from the axonal end plates of these nerves within the corpora cavernosa causes relaxation of smooth muscle, initiating the haemodynamic changes of penile erection as well as contributing to maintained tumescence; the loss of CN function is primarily responsible for the development of erectile dysfunction (ED) after pelvic surgery and serves as the primary target for potential neuroprotective or regenerative strategies. Evidence from pre-clinical studies for select neuromodulatory approaches is reviewed, including neurotrophins, glial cell line-derived neurotrophic factors (GDNF), bone morphogenic proteins, immunophilin ligands, erythropoetin (EPO), and stem cells.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Mental Health and Behavioral Disorders
Database:
WPRIM (Western Pacific)
Main subject:
Penis
/
Postoperative Complications
/
Therapeutics
/
Erythropoietin
/
Neurotransmitter Agents
/
Brain-Derived Neurotrophic Factor
/
Bone Morphogenetic Proteins
/
Immunophilins
/
Stem Cell Transplantation
/
Therapeutic Uses
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2008
Document type:
Article