Red yeast rice increases excretion of bile acids in hamsters / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 269-277, 2009.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-360665
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism.</p><p><b>METHODS</b>Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR (0.1RYR) or 0.3% RYR (0.3RYR). Blood (0.5 mL) was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0, 3, and 6. Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography.</p><p><b>RESULTS</b>Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by 11% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, liver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7alpha-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K. It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 3-4 folds compared with the control value.</p><p><b>CONCLUSION</b>Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Pharmacology
/
Biological Products
/
Blood
/
Body Weight
/
Bile Acids and Salts
/
Receptors, LDL
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Cholesterol 7-alpha-Hydroxylase
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Weight Gain
/
Chemistry
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2009
Document type:
Article