Clinical significance of expression of VEGF and bFGF in thyroid carcinoma / 中华外科杂志
Chinese Journal of Surgery
; (12): 864-866, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-360944
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical significance of expression of VEGF and bFGF in thyroid carcinoma.</p><p><b>METHODS</b>Immunohistochemical SP technic was used to investigate the expression of VEGF and bFGF in 90 cases of papillary carcinoma, 14 cases of undifferentiated carcinoma, 10 cases of normal thyroid tissue.</p><p><b>RESULTS</b>The positive rate of VEGF and bFGF in thyroid carcinoma was 63.5% and 59.6% respectively, Which was significantly higher than that in normal thyroid tissue (P < 0.01); The positive rate of VEGF and bFGF in undifferentiated carcinoma was 92.9% and 85.7% respectively, which was significantly higher than that in papillary carcinoma (P < 0.05); The positive rate of expression of VEGF and bFGF was correlated with lymph gland metastasis (P < 0.05); A positive correlation between these two expresses existed in thyroid carcinoma (gamma = 0.596, P < 0.05).</p><p><b>CONCLUSION</b>VEGF and bFGF can be regarded as a parameter to evaluate the biological behavior and prognosis of thyroid carcinoma.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Thyroid Neoplasms
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Immunohistochemistry
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Carcinoma
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Carcinoma, Papillary
/
Fibroblast Growth Factor 2
/
Vascular Endothelial Growth Factors
/
Lymphatic Metastasis
/
Metabolism
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2004
Document type:
Article