Treatment of Heart Failure in Eight Cases with Hyperthyroidism by Saikokarhukotsuboleito / 日本東洋医学雑誌

ABSTRACT

Eight cases with heart failure in hyperthyroidism treated by <I>Saikokarhukotsuboleito</I> extract were reported. All patients, 2 males and 6 females aged 30-71, were diagnosed as hyper-thyroidism by physical findings, serum thyroid hormone assay and TRH test. Heart failure with various severity from edema of the legs to pulmonary edema occurred in 3 untreated patients and during antithyroid therapy with beta blockade in 5 patients. After administration of <I>Saikokarhu-kotsuboleito</I> extract with antithyroid drug and beta blockade in 5 patients, with only antithyroid drug in 2 patients and no other medications in 1 patient, all patients recovered from the heart failure in 3-21 days. These observations in hyperthyroidism suggest that in the classical indications for administration of <I>Saikokarhukotsuboleito</I>, “startle and confusion” and “talk in delirium” would be neuropsychotic states caused by adrenergic hyperactivity and “fullness in the chest”, “dysuria” and “heavy sen-sation in the whole body and difficulty to turn over or lie down” would be states caused by high output heart failure.