Meta-Analysis of the SLCO1B1 c.521T>C Variant Reveals Slight Influence on the Lipid-Lowering Efficacy of Statins
Annals of Laboratory Medicine
; : 329-335, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-36806
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Several studies have focused on the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism; however, the results are conflicting. The effects of statins show significant variability between individuals. This meta-analysis aimed to investigate the effects of the SLCO1B1 c.521T>C polymorphism on the lipid-lowering effects of statins.METHODS:
We systematically searched PubMed and Web of Science to screen relevant studies. Meta-analysis was performed to identify the association between SLCO1B1 c.521 polymorphisms and the lipid-lowering effects of statinson the basis of the standard mean difference (SMD) and 95% confidence intervals (CIs). Additionally, we checked for heterogeneity (I 2) among studies and evidence of publication bias. We obtained eight studies including 2,012 wild genotype (T/T) and 526 variant genotype (T/C and C/C) cases.RESULTS:
No significant difference was observed in the lipid-lowering efficacy of statins between the wildand variant genotypes of SLCO1B1, with a pooled SMD of 0.03 (95% CI -0.07-0.13). Furthermore, there was no significant effect in the meta-analyses of the variant heterozygote, homozygote, and Chinese populations. Subgroup meta-analysis indicated that the timerequired for the statin to take effectdid notsignificantly affect the association between lipid-lowering efficacy of statins and SLCO1B1 c.521T>C polymorphism. However, thewild genotype improved the lipid-lowering efficacy of simvastatin with a pooled SMD of -0.26 (95% CI -0.47- -0.05).CONCLUSIONS:
No significant association was detected between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism, with the exception of simvastatin.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Databases, Factual
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Polymorphism, Single Nucleotide
/
Liver-Specific Organic Anion Transporter 1
/
Alleles
/
Genotype
/
Hyperlipidemias
Type of study:
Systematic review
Limits:
Humans
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2015
Document type:
Article