Antitumor Activity of a Hot Water Extract of <I>Flammulina velutipes</I> Sing / 日本農村医学会雑誌
Journal of the Japanese Association of Rural Medicine
; : 650-655, 1982.
Article
in Japanese
| WPRIM (Western Pacific)
| ID: wpr-377366
Responsible library:
WPRO
ABSTRACT
A hot water extract of <I>Flammulina velutipes</I> Sing.(FEH-1) showed a markedly high antitumor effect against sarcoma 180 in ICR mice. FEH-1 (10mg/kg) was administered intraperitoneally for consecutive 21 days before and after the subcutaneous inoculation of sarcoma 180 (4.1X10<SUP>6</SUP> cells) to the mice. Animals were sacrificed on the 24th day after the inoculation of sarcoma 180 and tumor weight was determined. The highest tumor inhibition ratio was 98.5%, when FEH-1 was administered at the dose of 10mg/kg.<BR>Cytotoxicity of FEH-1 was denied by the following two tests(1) after mixed-culture of Vx2 tumor cells with FEH-1 for 7 days <I>in vitro</I>, number of Vx2 cells was counted by dye-exclusion technique, and (2) after contact of Vx2 cells with FEH-1 for 1 hour, the cell mixture was inoculated subcutaneously to the rabbits. It was suggested that antitumor effect of FEH-1 was host-mediated.
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Database:
WPRIM (Western Pacific)
Language:
Japanese
Journal:
Journal of the Japanese Association of Rural Medicine
Year:
1982
Document type:
Article