Perspectives on surveillance of microbiol resistance / 中华检验医学杂志

ABSTRACT

The purpose of setting project of surveillance of antimicrobial resistance is:(1)To better understand development of resistance in local hospital,or country,and to compare with data from other countries;(2)To cooperate with clinic for controlling outbreak caused by clone strain-resistance;(3)To help doctors for management of treatment;and(4)To mining the mechanisms of resistance.In this text the history of surveillance of antimicrobial resistance in Peking Union Medical College Hospital starting in 1983 to present and the achievement were ihtroduced.But the fight against resistance between human being and microorganism is eternal and difficult.The main target pathogens and antimicrobial resistance at 21 st sentry were also introduced.The paper emphasized necessity and possibility of distinguishing CA-MRSA and HA-MRSA,VRSA,VISA and hVISA,ESBLs,AmpC and carbapenemases.To pay more attention to the relationship between resistance and serotypes in Streptococcus pneumoniae,it is important to survey the emerging resistance of the new antibiotics in China,such as linezolid,tigecycline,daptomycin,ceftobiprole and new fluoroquinolones and others.It is needed to develop pharmacokinetic/pharmacodynamic(PK/PD)- breakpoints as a substitute for old breakpoints,and to introduce emerging technologies,such as data mining artificially intelligent system,geographic information system,multiplex real time PCR with advanced reading techniques and other molecular methods for routine work in Clinical microbiology,SO that we can wisely fight against microbial resistance effectively.