Expression and clinical significance of Topo Ⅱα , COX-2 in breast cancer tissues / 肿瘤研究与临床
Cancer Research and Clinic
; (6): 100-102, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-382699
Responsible library:
WPRO
ABSTRACT
Objective To explore the expression of Topo Ⅱα and COX-2 in breast cancer tissues and investigate their correlations to clinicopathologic feature of breast cancer. MethodsThe expression of Topo Ⅱα and COX-2 in 50 specimens of breast cancer and their normal tissues were detected by immunohistochemistry. Their correlation to clinicopathologic features of breast cancer were analyzed.ResultsThe positive rates of Topo Ⅱα were 64 % (32/50) and 22 % (11/50) and COX-2 were 68 % (34/50) , 14 %(7/50) in breast cancer and normal tissue (P<0.05). The expression of Topo Ⅱα was correlated to degree of differentiation (P <0.05), not correlated to patient age, tumor size, clinical stage and lymph node metastasis(P >0.05). The expression of COX-2 was correlated to tumor size, degree of differentiation, clinical stage and lymph node metastasis (P <0.05), not correlated to patient age (P >0.05). Conclusion Topo Ⅱα and COX-2 expression can be used as an indicator for predicting the differentiation, infiltration and metastasis characteristics of breast cancer.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2011
Document type:
Article