Role of VEGF-C in metastasis of non-small cell lung cancer / 肿瘤研究与临床

ABSTRACT

Vascular endothelial growth factor-C (VEGF-C) can promote the growth of tumor thymphangiogenesis by binding with receptor VEGFR-2 and VEGFR-3. It is an important factor of tumor lymphatic metastasis. Lymphatic metastasis is the major diffusion way for non-small cell lung cancer(NSCLC).The over expression of VEGF-C is significantly correlated to metastasis and prognosis of NSCLC. This article rewiews the bionomics and the functions of VEGF-C in metastasis of NSCLC.