Compound anisodine use as a role in traumatic optic neuropathies treatment: a meta-analysis / 中华眼底病杂志

ABSTRACT

Objective To estimate the quality and efficacy of the academic thesis of compound anisodine in traumatic optic neuropathies(TON)treatment. Method We searched Chinese database last or"blunt trauma"as key words,and analyzed them using the standard of evidence-based medicine(EBM).Result 6 RCTS with a total of 415 eyes included are retrieved,and the OR value is 6.54 with a 95%CI of[4.14,10.35],P＜0.00001,the difference is significant;sub-category analyses are made and both show significant difference(P＜0.0001). Conclusion The existing evidence supports that prognosis of TON is better when compound anisodine are adopt in treatment,and this effect is significant in steroid treatment.Compound anisodine can be used alone for TON treatment.However.because there are only 6 thesis are retrieved and all of them have methodological short-comings,the evidence is not convincing.There is an urgent need of well-planed,large-scale and multiple-center studies to assess the role of compound anisodine in traumatic optic neuropathies treatment.