CCL21/CCR7 axis and mechanisms of tumor invasion and metastasis / 国际肿瘤学杂志
Journal of International Oncology
; (12): 96-99, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-384214
Responsible library:
WPRO
ABSTRACT
Secondary lymphoid tissue chemokine (CCL21) is a double-edged sword, which exerts antitumor, anti-infection immune response by binding to the receptor CCR7 on the surface of the multiple immune cells. However, a variety of tumor cells also express the receptor CCR7, the combination of CCL21 with CCR7promotes the invasion and metastasis of tumor cells, leading to the facilitation of tumor development. Therefore,exploring the mechanism(s) of tumor invasion and metastasis might be helpful for use of CCL21 as tumor gene therapy through blocking of CCL21's promotion of tumor invasion and metastasis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2011
Document type:
Article