The factors influencing thrombolytic therapy in patients with ischemic stroke in Qingdao area / 国际脑血管病杂志

ABSTRACT

Objective To identify the thromolysis rate in patients with ischemic ccrebrovascular disease in Qingdao area and to analyze the causes of influcncing thrombolytic therapy and investigate their influencing factors. Methods We adopted a unified questionnaire about the status of diagnosis and treatment of stroke in Qigndao. The patients with acute stroke in the 11 departments of neurology of Qingdao municipal and county hospitals (all with thrombolytic conditios) from October 1,2008 to October 31,2009 were collected retrospectively. A face to face questionnaire survey was performed, their clinical data were collected and the factors of influencing thrombolytic therapy were analyzed. Results Actually 864 patients with ischemic eerebrovascular disease were investigated. Only 10 patients received thrombolytic therapy. The thrombolysis rate was 1.16%, and the thrombolysis rate within a 4.5-hour time widow was 6. 33 %. Logistic regression analysis showed that in addition to thrombolytic contraindications,the factors that influencing thrombolytic therapy in patients with acute ischemic stroke included the treatment in different level-hospitals (OR =0.061,95% CI O. 006-0. 703, P =0. 040) and the United States National Institutes of Health Stroke Scale (NIHSS) score (OR = 0.810,95% CI 0. 729-0.900, P = 0.000) at presentation. Conclusions The thrombolysis rate in patients with cerebrovascular disease in Qingdao area was relatively lower. In addition to thrombolytic contraindications, the factors that influencing thrombolytic therapy in ptients with acute ischemic stroke included the treatment in different level-hospitals and NIHSS score at presentation.