Relationship between GRIM-19 and cancers / 国际外科学杂志
International Journal of Surgery
; (12): 759-762, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-385661
Responsible library:
WPRO
ABSTRACT
Gene associated with retinoid-IFN-induced mortality-19(GRIM-19)is originally isolated as a growth suppressive gene using a genetic screen.GRIM-19, initially found in nucleus and mitochondria, is essential for the assembly and functioning of mitochondrial complex I.GRIM-19 involves the regulation of cell proliferation and apoptosis, and low expression or mutation of GRIM-19 contributes to abnormal proliferation.During viral oncogenesis, GRIM-19 may be a general target protein similar to other cellular tumor suppressors.GRIM-19 plays an important role in tumor formation and apoptosis inhibition, and may be as a new tumor marker to early cancer screening.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2010
Document type:
Article