Primary suggestions on the anti-viral drugs treatment in chronic HBV carriers / 中国综合临床

ABSTRACT

Objective To establish a standard anti-viral treatment for chronic HBV carriers. Methods With reference to the domestic and abroad literatures, the diagnostic and therapeutic standards were set and prepared to be verified. ResultsThe diagnostic standards included:(①ALT 30 -40 IU/L: add 2 scores. (②Age:30 -39 ,add 1 score; ≥40,add 2 scores. (③Ultrasound examination: obviously abnormal,add 1 score;deteriorated during follow up:add 2 scores. ④Fibrosis markers positive: add 1 score. (⑤History of HCC in vertical relatives:add 1 score. ⑥ Existence of conditions which can induced elevation of ALT such as fatty liver or alcoholic liver or BMI ＞ 23 kg/m2,minus 2 scores. The therapeutic standards included:(①≥5 scores: should be treated;(②3 -4 scores: may be treated or just follow up;(③≤2 scores;follow up and reexamine every 6 months. ConclusionsThe above standards are preliminary suggestions which should be checked and rectified by liver biopsy to achieve a more accurate and more practical standard.