High mobility group Box-1 and pancreatic carcinoma / 国际肿瘤学杂志

ABSTRACT

As an intracellular non-histone chromosomal binding protein, High mobility group Box-1 ( HMGB1 ) plays an important role in maintaining the stability of the nuclear body and DNA recombination, duplication, repair and genetic transcription. Besides, extracelluar HMGB1 may serves as a "late inflammatory mediator", which start inflammatory response in the late stage of inflammation. Recent studies have found that,HMGB1 is closely related with the growth, infiltration and migration of pancreatic carcinoma. Also, HMGB1 can promote the degradation of extracelluar matrix, the infiltration and the migration of pancreatic carcinoma.