The disorder of bleeding and coagulation in the peritoneal dialysis patients / 中华器官移植杂志

ABSTRACT

Plasma level of KPTT,factor Ⅷ coagulant activity,factor Ⅷ-related antigen,fib-rinogen,antithrombin Ⅲ activity,antithrombin Ⅲ antigen,tissue-plasminogen activator activity (t-PAC),plasminogen activator inhibitor activity(PAIC),PAIC/t-PAC,plasmin activity (PLmC),D-dimer and plasma platelet α granule membrane protein were ditermined in 26 patients treated by long-term peritoneal dialysis(PD group),17 patients with chronic renal failure under-going conservative therapy(CRF group),36 patients on maintenance hemodialysis(HD group) and 20 age & sex-matched normal controls(NC group).The results showed1.PD group had hypercoagulable state than NC group.The prothrombotic state in PD patients was most severe in contrast with CRF patients and HD patients.2.When PD group was compared with NC group,PLmC showed no significant differences,but they had secondary fibrinolysis following enhanced coagulation.Moreover,PLmC in PD group was significantly depressed as compared with in CRF group.3.the activated platelets in the PD patients were significantly elevated as compared with in the normal controls.