Role of Svcam-1 in the pathogenesis of intrahepatic cholestasis of pregnancy / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 435-436, 2009.
Article
in Zh
| WPRIM
| ID: wpr-395738
Responsible library:
WPRO
ABSTRACT
Objoctive To investigate circulating leveh of soluble vascular cell adhesion molecule-1(sVCAM-1)in the peripheral of intrahepatic cholestasis of pregnancy(ICP).To reveal the pathogenesis of ICP.Methods Maternal scram sVCAM-1 levels were determined in 49 women which 15 eases were normal pregnant women and 34 with ICP.The latter were composed of 14 women with mild,20 with severe ICP.sVCAM-1 was measured by ELISA.Results The levels of serum sVCAM-1 was significantly elevated in women with mild and severe compared with control subjects(P<0.01),and markedly decreased to normal 5 days after dilively(P>0.05).The sVCAM-1 level were negatively correlated with weight of neonatal(r=-0.643,P<0.01).Conclusion Elevated levels of sVCAM-1 indicate that a primary endothelial cell dysfunction play an important role in the ICP.And it influences the neonatal.
Full text:
1
Database:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2009
Document type:
Article