Relationship of oncogene PCNA, nm23 expression in breast cancer and its prognostic significance / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 20-22, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-396326
Responsible library:
WPRO
ABSTRACT
Objective To investigate the relationship between PCNA and nm23 expression in breast cancer tissue and its prognosis. Methods Detected the expression of PCNA and nm23 of 278 cases of breast cancer by immunohistochemical technique S-P and analyzed it combined with the clinicopathology. Results PCNA positive rate was 37.4%(104/278),nm23 positive rate was 59.7%(166/278).PCNA and nm23 genes expression had no obvious correlation with the breast cancer pathological type,patients age and clinical stage (P > 0.05). PCNA expression had the positive correlation with the axillary lymph nodes meta-sitasis but negative to 5-year survival rates(P < 0.01 ),nm23 expression had the negative correlation with the axillary lymph nodes metasitasis but positive to 5-year survival rates(P < 0.01 ). PCNA and nm23 expression had the obvious negative correlation between them(P < 0.01 ). Conclusion Combined detection the expres-sion of PCNA and nm23 in breast cancer tissue will be important reference to forcast and evaluate the prognosis of the breast cancer patients.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Postgraduates of Medicine
Year:
2008
Document type:
Article