Delta-like ligand 4 and tumour angiogenesis / 国际外科学杂志
International Journal of Surgery
; (12): 116-119, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-396397
Responsible library:
WPRO
ABSTRACT
Delta-like ligand 4(Dll4), one ligand of Notch receptors, is highly expressed in tumour vessels and is negative regulator in tumour angiogenesis. Blocking Dll4/Notch sinaling could promote tumour angiogenesis, whereas due to poor perrusion of newly forming vessels, tumour growth is inhibited, which is effective even to the tumour patients unresponsive to blocking vascular endothelial growth factor pathway. So, Dll4 is becoming a new promising target in anti-tumour theraties.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2009
Document type:
Article