Endothelial Progenitor Cells and Cell Therapy of Ischemic Cerebrovascular Disease / 国际脑血管病杂志

ABSTRACT

Endothelial progenitor cells(EPCs)are the precursor cells of vascular endothelial cells.EPCs are in bone marrow,peripheral blood and cord blood.They participate in the process of angiogenesis after birth.The stimulation of exogenous and endogenous factors mobilizes bone marrow-derived EPCs into peripheral blood,and participates in the revascularization of ischemic tissue and the process of re-endothelialization of the injured blood vessels.The decreased mmahers and quality of EPCs in blood circulation are one of the most important factors of unfavourable prognosis after ischemic stroke.The transplantation of EPCs may provide a novel therapeutic strategy for the treatment of ischemic cerebrovascular disease.