Cytokines expression in the membranous tissue and organized thrombi in membranous obstruction of Budd Chiari syndrome / 中华普通外科杂志

ABSTRACT

Objective To explore the relationship between the membranous tissue(MT)and organized thrombus(OT)in membranous obstruction of the inferior vena cava(MOVC),we investigated the related cytokines expression in the membranous tissues in MOVC as well as venous organized thrombi. Methods Using immunohistochemical method the expression of TGFβR,PDGFR,ET-1,FⅧ-rAg, ferritin and α1-antitrypsin were observed in the membranous tissues in 11 cases with MOVC and organized thrombi in 8 cases with deep venous thrombosis(DVT). Results Expression rates of TGFβR,PDGFR,ET-1,FⅧ-rAg, and ferritin in membranous tissues in 11 cases with MOVC and organized thrombi in 8 cases with DVT were as follows TGFβRMT 72.3%,OT 50%(P＞0.05);PDGFRMT 45.5%,OT 100%(P＜0.05＝;ET-1MT 100%,OT 0(P＜0.05＝;FⅧ-rAg MT 90.9%,OT 12.5%(P＜0.05＝;ferritin MT 72.3%,OT 100%(P＞0.05).α1-antitrypasin was not detected in either membranous tissues of MOVC or organized thrombi of DVT. Conclusions ThrovIgh the investigation of the related cytokines expression, it is possible that membranous tissue formation in MOVC is related to the organized thrombus.