The expression and significance of RUNX3 gene in hepatocellular carcinoma / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 17-19, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-399101
Responsible library:
WPRO
ABSTRACT
Objective To evaluatethe expression and significance of RUNX3 gene and protein in hepatocellular carcinoma.Method Reverse transcription-polymerase chain resction (RT-PCR) and immunoitistochemistry SP method were used to detect the expressions of RUNX3 gene and protein in 23 cases of hepatocellular carcinoma and their adjacent non-cancerous tissue.Results The expression of RUNX3 gene and protein were significantly reduced in hepatocellular carcinoma tissue (26.1% and 17.4% respectively),which were prominently lower than those in adjacent non-cancerous tissue91.3% (21/23) and 87.0% (20/23),P<0.01.Conclusion The lower-expression of RUNX3 gene and protein may play an important role in hepatocellular carcinoma.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Postgraduates of Medicine
Year:
2008
Document type:
Article