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Interaction of SNP in non-coding region between estrogen receptor alpha gene and brain-derived neurotrophic factor (BDNF) gene in late-onset Alzheimer's disease in southern Chinese Han population / 中国神经精神疾病杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-405101
Responsible library: WPRO
ABSTRACT
Objective To study the interaction of BDNF gene C270T polymorphism and estrogen receptor alpha (ERα)gene Xba Ⅰ loci and Pvu Ⅱ loci polymorphism in late-onset Alzheimer's disease(LOAD)pathogenesis in southern Chinese Han population.Methods BNDF gene C270T locus,ERα gene Xba Ⅰ site and Pvu Ⅱ site polymorphisms were examined in 203 LOAD patients and normal controls using PCR-RFLP technique.Results There was an interaction be-tween BDNF gene and ERα gene,and BDNF gene C270T locus CC genotype and the ERa gene Xba Ⅰ locus xx genotype increased the LOAD incidance risk(OR=2.38,95%CI1.02~5.53).Conclusions BDNF gene and ERα gene are in-teracted each other in the pathogenesis of LOAD.Patients carrying both BDNF gene C270T locus CC genotype and the ERα gene Xba Ⅰ locus xx genotypes might have an increased risk for LOAD.

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Nervous and Mental Diseases Year: 2009 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Nervous and Mental Diseases Year: 2009 Document type: Article
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