Characteristics of molecular biology of tropomyosin and its correlation with the occurrence of myopathy

Jingxian YANG

ABSTRACT

OBJECTIVE:

To retrospect the experiments and clinical research on tropomyosin(TM) and make sure the 4 genes of TM in mammals and the relationship between its gene mutation and weakness of skeletal muscle as well as hypertrophic cardiomyopathy in order to provide support for preventative measures and rehabilitation interventions. DATA SOURCESConducting computerized search on experiments and clinical reports from January 1987 to Augsut 2004 regarding TM to Medline and Wanfang Database.The key searching words of " tropomyosin, gene, mutation" both in English and Chinese were used with the restricted language of English and Chinese respectively. DATA SELECTIONThe fiirst trial was conducted to the found literatures while the articles with " single case,experience" in title and non-research ones were excluded. Then full text of the rest reports was searched.Randomized control clinical trial(RCT) was used as the selective standard. DATA EXTRACTIONThere were 30 articles found regarding the randomized and non-randomized trials on the research and advance of molecular biology of TM with 21 of them met the selective standard and 9 articles were excluded. DATA

SYNTHESIS:

The study showed that TM was an important regulatory protein for muscle contraction,which existed widely in various kinds of eukaryotes in the way of isomers. Four TM genes of mammals had been confirmed by which 20 TM isomers could be expressed.Different TM gene could induce different diseases respectively.

CONCLUSION:

At present,research of TM is not just limited to the process of muscle contraction,study on its effects on the conversion of vascular smooth muscle cell has been attached much attention.The application of gene engineering will essentially diagnose and cure the disease therefore medical behaviors and quality of life will be consequently changed.