The Clinicopathological Study On The Relation Of Microvessel Density And Aggressiveness In Oral Squamous Cell Carcinoma
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 155-160, 2002.
Article
in Ko
| WPRIM
| ID: wpr-41018
Responsible library:
WPRO
ABSTRACT
Oral squamous cell carcinoma (OSCC), the most common head and neck cancer, shows poor prognosis as a result of frequent local invasion and lymph node metastasis that is mediated by multiple proteolytic enzymes and angiogenesis. In recent reports, angiogenesis is known to play an important role in tumor invasion and metastasis. The purpose of this study was to determine the role of angiogenesis in OSCCs, particularly with respect to the invasive and the metastatic potential. The microvessel density (CD31) in 34 human OSCC cases were investigated by immunohistochemistry, and reviewed with respect to the invasiveness and the presence of lymph node metastasis and following results were obtained. The blood vessel density (28.8+/-7.9) in the strong invasive cases were significantly higher than those (23.3+/-6.9) in the weak invasive cases. (p 0.05) These results suggest that angiogenesis may be related to the local invasion of OSCC and further research will be needed to investigate the possibility that antiangiogenic agent can be used as an anticancer agent for OSCC.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Peptide Hydrolases
/
Prognosis
/
Blood Vessels
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Microvessels
/
Hand
/
Head and Neck Neoplasms
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2002
Document type:
Article