Collagen Distribution and its Quantitative Variation in the Aortic Adventitia of Spontaneously Hypertensive Rats / 中华高血压杂志
Chinese Journal of Hypertension
; (12): 50-52, 2001.
Article
in Zh
| WPRIM
| ID: wpr-411642
Responsible library:
WPRO
ABSTRACT
Objective: To study collagen distribution and its quantitative variation in t he aortic adventitia of spontaneously hypertensive rats Methods: Sirus red stain was used to observe collagen distribution in aortic adventitia;Chloramine-T oxidation assay was employed to quantitate the collagen of aortic adventitia;Immuno-histochemical staining was adopted to detect type Ⅰ、Ⅲ collagen synthetic characteristic of vascular adventitial fibroblasts. Results: Collagen of rat aoritc wall mainly distributes in adventitia;SHR shows more collagen deposition in adventitia than WKY at the age of 8weeks and 24 weeks;The immuno-histochemical staining of type Ⅰ、Ⅲ collagen in vascular a dventitial fibroblasts is positive. Conclusions: All those results indicate that vascular adventitia ma y be involved in hypertensive vascular remodeling.and vascular adventitial fibroblasts can synthe size collagen type Ⅰ and Ⅲ.
Full text:
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Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Hypertension
Year:
2001
Document type:
Article