STUDY ON ADRIAMYCIN-POROUS TRICALCIUM PHOSPHATE CERAMIC DRUG DELIVERY SYSTEM AND ITS DRUG RELEASE TEST IN VIVO / 中国修复重建外科杂志
Chinese Journal of Reparative and Reconstructive Surgery
; (12): 12-14, 2001.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-411998
Responsible library:
WPRO
ABSTRACT
Objective To manufacture adriamycin-porous tricalcium phosphate (A-PTCP) ceramic drug delivery system (DDS)as a possible method for bone defect treatment after bone tumor operation. Methods A-PTCP DDS was made from putting adriamycin into PTCP. Thirty rabbits were divided randomly into group A(24 rabbits) and group B(6 rabbits). A-PTCP was implanted in the greater trochanter of the right femur in group A. Adriamycin were injected into veins in group B. Muscle around A-PTCP and plasma were taken out at different period. Adriamycin concentrations in muscle and plasma were measured by high performance liquid chromatography (HPLC). Results A-PTCP could gradually release adriamycin over 10 weeks. Adriamycin concentrations in the muscle were higher than that in plasma. Conclusion A-PTCP may be a new method for repairing bone defects after bone tumor operation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Reparative and Reconstructive Surgery
Year:
2001
Document type:
Article