Clinical use of mearing antithyroid peroxidase antibody in autoimmune thyroid disease / 西安交通大学学报(医学版)

ABSTRACT

ObjectiveTo investigate the clinical application of TPO-Ab by comparing the relationship between TPO-Ab and TMAb in ATD. MethodsIn this study with the method of RIA, we measured the serum level of TPO-Ab and TMAb in 200 ATD patients, 50 patients with non-ATD and 30 normal controls, and analyzed the relationship of TPO-Ab and TMAb, compared the differ ence between TPO-Ab and TMAb for diagnosis ATD. ResultsTPO-Ab titer increased in ATD es pecially in Hashimoto's thyroiditis(P＜0.01), at the same time it could influence the state of the throid function. A significant positive correlation was found between TPO-Ab and TMAb(γ= 0.83,P＜0.01 ), but TPO-Ab appeared to be more sensitive and specific for diagnosising Hashimoto's thy roiditis than TMAb. ConclusionTPO-Ab is a sensitive and specific stantard for diagnosising ATD.