Correlation between polymorphism of angiotensin converting enzyme gene and hypertensive disorder complicating pregnancy in Chinese population:a meta-analysis / 中华围产医学杂志
Chinese Journal of Perinatal Medicine
; (12): 92-97, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-413606
Responsible library:
WPRO
ABSTRACT
Objective To explore the correlation between polymorphism of angiotensin converting enzyme (ACE) gene and hypertensive disorder complicating pregnancy (HDP) in Chinese people.Methods The 21 case-control studies on the correlation between polymorphism of ACE gene (genotype DD,DI,Ⅱ) and HDP in Chinese people were analyzed by meta-analysis.The analysis was performed on Review Manager 4.2 software.According to the result of test for heterogeneity,the random effects model was used to calculate the pooled OR value and 95% CI.Results Twenty-one case-control studies were enrolled in this meta-analysis,a total of 1486 HDP cases and 1758 controls were included.The pooled OR values (95% CI) of DD,DI,Ⅱ genotypes of ACE gene polymorphism for HDP risk were 2.60 (1.84-3.67),0.98 (0.76-1.27) and 0.46 (0.32-0.65) respectively.Conclusions Genotype Ⅱ of ACE is a protective gene against HDP and genotype DD is a susceptibility gene for HDP.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Observational study
/
Risk factors
/
Systematic review
Language:
Chinese
Journal:
Chinese Journal of Perinatal Medicine
Year:
2011
Document type:
Article