Review and prospect forecast of photodynamic therapy which is kind of generational treatment for choroidal neovascularization / 中华眼底病杂志

ABSTRACT

Photodynamic therapy is the first treatment confirmed to be effective in the treatment of exudative age-related macular degeneration in 2000,which had been introduced to China in the same year.The pathological new vessels were destructed by the singlet oxygen and oxygen free radical released by activated photosensitizer.In the next 12 years,it has been widely applied for the treatment of subfoveal and parafoveal choroidal neovascularization caused by all kinds of chorioretinal diseases.More than a treatment,it also help us to explore the pathogenesis of fundus disease,the capability to embolize the capillaries within the treating area let us not only understand the mechanism of central serous chorioretinopathy and polypoidal choroidal vasculopathy,but also make it a effective cure for them.However,there are still a lot of unsolved questions such as the mechanism of photodynamic therapy,the relationship with human genomic difference,and even the development of angiogenesis.Besides with the more novel medications and strategies available,we also face the appropriate application for indications,selection of combined therapy and optimization of treatment regimens.Further investigations about the photodynamic therapy and disease and their relations from both basic and clinical study will guide us the treatment in clinic and also reveal the truth of related fundus diseases deep under the surface.