Histone deacetylases regulate angiogenesis: a possible treatment strategy of improving stroke / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 627-630, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-420298
Responsible library:
WPRO
ABSTRACT
Currently,the most effective treatment for acute ischemic stroke is administration of tissuetype plasminogen activator for intravenous or intra-arterial thrombolysis within 3 to 6 hours after symptoms onset.However,the narrow therapeutic time window and the risk of intracranial hemorrhage have limited its clinical application.Angiogcncsis refers to the process of the formation of new functional blood vessels with the manner of germination from the already existing network of blood vessels.An increasing number of studies have shown that histone deacetylases involve in the regulation of angiogenesis.It may become a potential stroke treatment strategy.This article reviews the role of histone deacetylases in the regulation of angiogenesis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2012
Document type:
Article