Histone modification and neural stem cell differentiation / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 717-720, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-420310
Responsible library:
WPRO
ABSTRACT
Neural stem cell (NSC) has self-renewal and differentiation potential.It can orderly differentiate into neurons,astrocytes and oligodendrocytes in the development of central nervous system.NSC differentiation was commonly regulated by a variety of factors,including cytokines,transcription factors and epigenetic factors.Epigenetic regulation is a heritable gene expression without changing the DNA sequence.Histone modification is an important regulation mode in epigenetic modifications,which is essential in the transcription process.It also plays a critical role in the development of central nervous system.This article briefly reviews the histone methylation and demethylafion in the regulation of NSC differentiation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2012
Document type:
Article