Polymorphism of gamma-glutamyl hydrolase and methotrexate sensitivity / 国际儿科学杂志
International Journal of Pediatrics
; (6): 497-500, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-421331
Responsible library:
WPRO
ABSTRACT
Gamma-glutamyl hydrolase (GGH) plays an important role in methotrexate (MTX)polyglutarmation. High level of GGH has been associated with cellular resistance to MTX. Recent studies have demonstrate that some polymorphisms of GGH could change the expression and catalytic activity of the enzyme,causing interindividual difference in MTX cytotoxicity. No study about GGH was reported in Chinese population. This paper reviewed the advances about the structure and function of GGH and its gene, and the advances in associations between polymorphisms of GGH and MTX sensitivity.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2011
Document type:
Article