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Progress of CD4 + CD25 + regulatory T cells in pathogenesis of idiopathic thrombocytopenic purpura / 国际儿科学杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-421338
Responsible library: WPRO
ABSTRACT
CD4 + CD25 + regulatory T cells(Treg) are thought to be a subgroup of mature CD4 + T cells.Forkhead winged helix transcription factor-3 (Foxp3)is specifically expressed on them and plays a key role in their development and function. CD4 + CD25 + Treg cells can maintain the stabilization of internal environment by two principal pathways to suppress the immunological function the direct suppression of the target cells by cell-contact and the secretion of suppressor cytokines.At present,it has been considered that decreased number and dysfunction of CD4+ CD25+ Treg cells are closely related to pathogenesis of autoimmune disease. Recent findings show that CD4+ CD25+ Treg cells play an important role in pathogenesis of idiopathic thrombocytopenic purpura.

Full text: Available Database: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: International Journal of Pediatrics Year: 2011 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: International Journal of Pediatrics Year: 2011 Document type: Article
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