Indoleamine-pyrrole 2,3-dioxygenase might be a prognostic biomarker for patients with renal cell carcinoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 649-655, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-424051
Responsible library:
WPRO
ABSTRACT
Objective:
To explore the role of indoleamine-pyrrole 2,3-dioxygenase (IDO),an immunomodulatory enzyme,in renal cell carcinoma (RCC).Methods:
A total of 40 patients diagnosed as RCC in the Second Xiangya Hospital were included in this study.All patients received nephrectomy.The histopathological features of samples were assessed semi-quantitatively.IDO mRNA level in RCC and non-RCC renal tissues was determined by real-time quantitative PCR (RT-qPCR).And the expression of IDO protein in endothelial cells was examined by immunohistochemistry; a Kaplan-Meier survival curves was calculated on the basis of IDO mRNA level.Results:
Level of IDO mRNA in RCC samples was significantly higher than that in tumor-free samples with P<0.001.Patients with high IDO expression had an significantly longer survival time than those with low IDO expression (P=0.01).There was a statistically significant inverse correlation between IDO and proliferation marker Ki67.Patients with high IDO level were of low Ki67 level,and vice versa (P<0.01).Conclusion:
IDO might be a prognostic biomarker for patients with RCC.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2012
Document type:
Article