On the expression of cytokine in monocyte by intermittent high glucose / 中华内分泌代谢杂志

ABSTRACT

The mechanism of damage in monocytes with the oxidation inhibitor α-lipoic acid (ALA) was observed under intermittent high glucose condition.The results showed that fluctuating high blood glucose levels led to more damage than that under constant high blood glucose level in monocyte,and antioxidant α-ALA could ameliorate the oxidative stress.The high level of nuclear factor-κB and monocyte chemotactic protein-1 are probably among the factors that cause vascular damage by deposit of monocytes.