The effect of metformin on expression of vaspin mRNA in insulin resistant rats induced by high-fat diet / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 231-234, 2012.
Article
in Zh
| WPRIM
| ID: wpr-425037
Responsible library:
WPRO
ABSTRACT
High-fat diet-induced insulin resistance rat model was assessed by euglycemic-hyperinsulinemic clamp technique.Compared with the control group,the vaspin mRNA expression in adipose tissue was significantly decreased in insulin resistant rats induced by high-fat diet( P<0.05 ),which was increased by metformin( P<0.05 ).These data indicate that metformin may ameliorate insulin resistance in rats via upregulating vaspin mRNA expression.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2012
Document type:
Article