Effect of Iron-Chelator Deferiprone on the In Vitro Growth of Staphylococci
Journal of Korean Medical Science
; : 289-295, 2009.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-42857
Responsible library:
WPRO
ABSTRACT
The standard iron-chelator deferoxamine is known to prevent the growth of coagulase-negative staphylococci (CoNS) which are major pathogens in iron-overloaded patients. However, we found that deferoxamine rather promotes the growth of coagulase-positive Staphylococcus aureus. Accordingly, we tested whether deferiprone, a new clinically-available iron-chelator, can prevent the growth of S. aureus strains as well as CoNS. Deferiprone did not at least promote the growth of all S. aureus strains (n=26) and CoNS (n=27) at relatively low doses; moreover, it could significantly inhibit the growth of all staphylococci on non-transferrin-bound-iron and the growth of all CoNS on transferrin-bound iron at relatively high doses. At the same doses, it did not at least promote the growth of all S. aureus strains on transferrin-bound-iron. These findings indicate that deferiprone can be useful to prevent staphylococcal infections, as well as to improve iron overload, in iron-overloaded patients.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pyridones
/
Staphylococcus
/
Staphylococcus aureus
/
Transferrin
/
Microbial Sensitivity Tests
/
Iron Chelating Agents
/
Iron Overload
/
Deferoxamine
/
Iron
Limits:
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2009
Document type:
Article