Expression of nuclear factor-kappa B and zinc finger protein A20 in keloid / 中华医学美学美容杂志
Chinese Journal of Medical Aesthetics and Cosmetology
; (6): 286-289, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-429115
Responsible library:
WPRO
ABSTRACT
Objective To investigate the protein and mRNA expression of NF-κB and zinc finger protein A20 in the keloid and normal skin and to explore its underlying molecular biological mechanism.Methods The protein and mRNA expression of NF-κB p65 and zinc finger protein A20 in keloid and normal skin was detected by immunohistochemistry and real time quantitative reverse transcription-polymerase chain reaction (RT-PCR).Results The protein and mRNA expression of NF-κB p65 in keloid tissues was higher than those in normal skin tissues (P<0.05).The protein and mRNA expression of zinc finger protein A20 in keloid tissues was lower than those in normal skin tissues (P<0.05).Conclusions NF-κB signal pathways and zinc finger protein A20 could play a role in keloid pathogenesis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Medical Aesthetics and Cosmetology
Year:
2012
Document type:
Article