Research advances on CO2 pneumoperitoneum promoting invasion and metastasis of gastrointestinal cancer / 肿瘤研究与临床

ABSTRACT

The laparoscopic surgery is increasingly widely used in the treatment of malignant gastrointestinal cancer.Its technical feasibility has been recognized,however,there are disagreements in the evaluation of its safety,the tumor metastasis of port-site and intra-abdominal after operation has been the focus of controversy in medical community.Its major impact mechanism including the change of peritoneal microenvironment,immunity,mechanical pressure of pneumoperitoneum,biological behavior of tumor cells and so on.The specification must be taken before surgery,strictly control the laparoscopic gastrointestinal cancer surgery indications,minimize the pneumoperitoneum pressure,shortem operative time,with He gas instead of CO2 pneumoperitoneum or free pneumoperitoneum laparoscopic techniques and other effective measures to reduce the risk of tumor metastasis.