Correlation factors of liver injury in infectious mononucleosis / 中国医师进修杂志

ABSTRACT

Objective To investigate the correlation factors of liver injury in infectious mononucleosis(IM).Methods One hundred and seventy-five IM patients were divided into two groupsIM with liver injury(patient group,85 cases)and IM without liver injury(control group,90 cases).Single factor and multiple factor analysis were completed by unconditional Logistic regression.Results Single factor analysis results showed that there were significance differences between the two groups in age(≥6 years old),male,course of disease,severe disease(involving ≥ 2 organs),heating time,the peak temperature,white blood cell(WBC)and C reactive protein(CRP),CD4+,CD8+,CD4+/CD8+,Epstein-Barr virus(EBV)-capsid antigen(CA)-IgM antibody positive and increased erythrocyte sedimentation rate(ESR)(P＜0.05).Age(≥ 6 years old),male,course of disease,severe disease(involving ≥2 organs),heating time,the peak temperature,WBC,CRP,CD8+,EBV-CA-IgM antibody positive and increased ESR showed positive correlation with IM combined with liver injury,and CD4+,CD4+/CD8+ showed negatively correlated with IM combined with liver injury.Multiple factor analysis results showed that severe disease(involving ≥2 organs),CD8+ high levels were independent risk factors for IM combined with liver injury,and CD4+ high levels and CD4+/CD8+ high were protection factors for IM combined with liver injury(P＜0.05).Conclusions Severe disease(involving ≥2 organs),CD8+ high levels are independent risk factors for IM combined with liver injury,and CD4+ high levels and CD4+/CD8+ high are protection factors for IM combined with liver injury.Therefore,immune modulators should be used to intervene the above factors when patients are treated with antiviral drugs.