Oncogenic mechanism and biological effect of Evi-1 gene / 国际肿瘤学杂志
Journal of International Oncology
; (12): 170-173, 2013.
Article
in Zh
| WPRIM
| ID: wpr-431527
Responsible library:
WPRO
ABSTRACT
Ecotropic viral integration site-1 (Evi-1) gene is first identified as a binding site for retrovirus in murine myeloid leukemia.The human homologue with the murine in leukemia oncogene Evi-1 is about 91% of nuclear sequence and 94% of amino acid.Evi-1 gene is high expressed in myeloid malignancies and other tumors.The main tumorigenic mechanisms of Evi-1 gene include inhibiting TGF-β signal path by depressing Smad3,adjusting cell cycle,promoting angiogenesis,inhibiting JNK.activating AP-1,and so on.
Full text:
1
Database:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Journal of International Oncology
Year:
2013
Document type:
Article